Healthcare Industry News:  MORAb-003 

Biopharmaceuticals Mergers & Acquisitions

 News Release - March 22, 2007

Eisai To Acquire Morphotek

Eisai's Dramatic Leap towards Biologic Therapeutics Evidenced by the Acquisition

TOKYO, Japan, WOODCLIFF LAKE, NJ and EXTON, PA, March 22 (HSMN NewsFeed) -- Eisai Co., Ltd. (Tokyo, "Eisai," President and CEO: Haruo Naito), Eisai Corporation of North America (Woodcliff Lake, NJ, "ECA," President: Hajime Shimizu) and Morphotek Inc. (Exton, PA, "Morphotek," CEO: Nicholas Nicolaides) today announce that ECA has signed a definitive agreement to acquire Morphotek for (US) $325 million after excess net cash.

Morphotek develops therapeutic monoclonal antibodies through the use of proprietary human antibody technologies, including Human MORPHODOMA and Libradoma (TM). The company is leveraging these technologies to enrich its pipeline that already includes therapeutic antibody leads for the treatment of cancer, rheumatoid arthritis, and infectious disease. Two of its programs are currently in early stage clinical trials for the treatment of ovarian cancer and pancreatic cancer, respectively, with several others in preclinical development.

Eisai currently has an extensive global oncology research program for discovering small molecule anti-cancer agents, and upon completion of the acquisition, will expand its capabilities into the biologic therapeutics field. With this unique and strategic antibody technology acquisition, Eisai can meet a variety of medical needs of cancer patients, through the development of therapeutic antibodies, small-molecule anti-cancer drugs, and potential combinations of both.

Mr. Naito said, "I sincerely respect Dr. Nicolaides' innovative and courageous endeavor in developing human monoclonal antibody therapeutics. He has made a tremendous contribution to that effort. By combining Morphotek's proprietary technologies and promising therapeutic antibodies with Eisai's existing research programs and infrastructure, we will be able to meet our goal of addressing the unmet medical needs of patients, especially cancer patients, all around the world. Morphotek's rich pipeline, unique and proprietary antibody generation technology platform, and highly skilled management and scientific team will become the core of our R&D efforts in biologics."

Dr. Nicolaides said, "Eisai's substantial intellectual and managerial resources will enable us to accelerate the development of our current therapeutic antibody pipeline as well as develop a number of additional clinical compounds to targets accessed from our broad network of research collaborations and to those discovered by Eisai researchers globally."

Dr. Ivor Royston, Chairman of Morphotek and Managing Partner of Forward Ventures added, "This is an excellent opportunity for Morphotek to join the Eisai organization and to further its founding mission of becoming a global leader in the development of innovative immunotherapies to treat serious diseases and to establish solutions for the health and well-being of people worldwide."

Upon completion of the transaction, Morphotek will become part of Eisai's growing global discovery and development research network, which is comprised of research laboratories in Japan, Europe and the U.S. The addition of Morphotek further extends Eisai's research presence in the U.S., which includes the Eisai Research Institute of Boston, Inc., a discovery operation based in Andover, Massachusetts, Eisai Medical Research Inc., for clinical development, located in Ridgefield Park, New Jersey, and RTP laboratory for formulation research, North Carolina.

"Morphotek will enjoy its autonomy in Eisai's discovery network but I will encourage close collaboration among all Eisai R&D member companies. We very much look forward to welcoming Morphotek to the Eisai family of companies," Mr. Naito concluded.

This planned expansion of Eisai's discovery, research and clinical capabilities complements Eisai's establishment of its oncology sales and marketing operations in the U.S. under ECA. Aided in part through its recent acquisition of four oncology-related products from Ligand Pharmaceuticals in October 2006, which included the retention of key oncology personnel and expertise including a sales force, Eisai has developed its commercial oncology infrastructure and is well positioned to market new oncology products that originate from Eisai's research and discovery efforts or through future acquisition, co-promotion or in-licensing opportunities.

The Morphotek acquisition, which has been approved by the boards of directors of ECA and Morphotek, is subject to clearance under the Hart-Scott- Rodino Antitrust Improvements Act and other customary closing conditions. It is expected to close sometime during Eisai's first fiscal quarter of 2007.

Mitsubishi UFJ Securities Co., Ltd. and Montgomery & Co. LLC are acting as financial advisors and Sullivan & Cromwell LLP is acting as legal counsel to Eisai in this transaction.

Lehman Brothers Inc. is acting as financial advisor and Cozen O'Conner LLP is acting as legal counsel to Morphotek in this transaction.

About Eisai Co., Ltd.

Eisai Co., Ltd. is a research-based human health care (hhc) company that discovers, develops and markets products throughout the world. Eisai focuses its efforts in three areas of therapeutic focus: Integrative neuroscience including neurology and psychiatric medicines; gastrointestinal disorders; and integrative oncology including oncotherapy and supportive-care treatments. Through a global network of research facilities, manufacturing sites and marketing subsidiaries, Eisai actively participates in all aspects of the worldwide health care system. Eisai employs more than 9,000 people worldwide and forecasts the group sales of (yen) 668 billion in FY2006. More than 50% of the group sales is derived from overseas business. For more information, visit

About Eisai Corporation of North America

Eisai Corporation of North America is a wholly owned subsidiary of Eisai Co., Ltd. and supports the activities of its operating companies in North America. These operating companies include: Eisai Research Institute of Boston, Inc., a discovery operation with strong organic chemistry capabilities; Eisai Medical Research Inc., for clinical development; Eisai Inc. for manufacturing and marketing/sales functions; and Eisai Machinery U.S.A. for marketing and maintenance of pharmaceutical manufacturing machinery.

About Morphotek

Morphotek, which was founded in 2000 and is located in Exton, Pennsylvania, and employs 45 people, is a privately held biopharmaceutical company which discovers and develops monoclonal antibodies for oncology, inflammatory and infectious diseases through the use of a proprietary human antibody technology called Human MORPHODOMA . The company has assembled a strong pipeline of lead products in the area of cancer, inflammation and infectious diseases. Morphotek's most advanced programs are MORAb-003, in Phase I/II for ovarian cancer, and MORAb-009, in Phase I for pancreatic cancer. There are several programs in preclinical stage moving towards IND filing. Its partners to date have included world-renowned research laboratories and leading biopharmaceutical companies. For further information, visit
    Morphotek's Pipeline:

    Clinical Stage   Product    Description/Mode        Target Disease
                     Name/Code     of Action

    Phase I/II       MORAb-003  Humanized IgG1 antibody Ovarian cancer

    Phase I          MORAb-009  IgG1 antibody           Pancreatic/Lung cancer

    Preclinical (IND MORAb-004  Humanized IgG1 antibody Melanoma/Neovascular
     preparation)                                        disease

    Preclinical (IND MORAb-022  Fully human IgG1        Autoimmune diseases
     preparation)                monoclonal antibody

    Preclinical      MORAb-028  Fully human IgM        Metastatic melanoma
                                 monoclonal antibody

    Preclinical      MORAb-047  Therapeutic antibody    Infectious disease

    Preclinical      MORAb-048  Therapeutic antibody    Infectious disease

    Eisai's Oncology Pipeline:

    Clinical Stage     Product     Description/Mode     Target Cancer
                      Name/Code       of Action

    Preparing for      E7389       Microtubule growth   Breast, Non-small
     Subpart H                      suppressor           Cell Lung, Prostate,
     submission                                          Ovarian, Sarcoma

    Phase I            E7070       Cell cycle G1 phase  Small Cell Lung
                                    targeting agent

    Phase I            E7820       Anti-angiogenesis    Various

    Phase I            E7080       Anti-angiogenesis    Various

    Phase I            E7974       Hemiasterlin type    Various

    Phase I in         E7107       Anti-tumor agent     Various
     preparation                    derived from
Major Technology Platform of Morphotek:

Fully-human monoclonal antibody generation and optimization [Human MORPHODOMA , Libradoma (TM)]


Human MORPHODOMA is able to generate fully human monoclonal antibodies. Furthermore, through the application of its proprietary technology and know-how, Morphotek is able to optimize the titer of its cell-lines, effect class switching, and enhance antibody affinity.

About Libradoma (TM)

The Libradoma (TM) technology process utilizes Human MORPHODOMA and other proprietary technologies to generate libraries potentially comprised of thousands of hybridomas that can be rapidly screened using high-throughput robotics to identify hybridomas expressing human antibodies with target affinity profiles.

Source: Eisai

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