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Devices Monitoring

 News Release - December 3, 2009

CAS Medical Systems, Inc. Announces Publication of Two Studies Demonstrating Use of FORE-SIGHT Absolute Cerebral Oximetry

BRANFORD, Conn., Dec. 3, 2009 -- (Healthcare Sales & Marketing Network) -- CAS Medical Systems, Inc. (Nasdaq:CASM ) today announced publication in the British Journal of Anaesthesia of two scientific studies demonstrating the use of the FORE-SIGHT(R) Absolute Cerebral Oximeter in various applications.

The first study (1), entitled "Reduced cerebral oxygen saturation measured by absolute cerebral oximetry during thoracic surgery correlates with postoperative complications", was conducted at the Department of Anaesthesiology, Montreal General Hospital, McGill University by Roy Kazan, David Bracco and Thomas Hemmerling. These researchers concluded that, in 50 patients undergoing thoracic surgery with greater than 45 minutes of single-lung ventilation, a significant decrease in cerebral tissue oxygenation was seen, and this correlated with post-operative cognitive dysfunction.

Professor Hemmerling, Director of the Intelligent Technologies in Anesthesia Group, stated, "Using absolute cerebral oximetry, we had recently detected very significant cerebral oxygen desaturations in patients undergoing thoracic surgery with single-lung ventilation to an extent previously only known from cardiac surgery. In this study, we found a 2-3 fold increase in the risk of developing postoperative complications in patients with absolute SctO2 values of 55% or less during single-lung ventilation. While the pathophysiology behind these desaturations necessitates further studies, at present we suggest to monitor cerebral oxygen saturations during single-lung ventilation and to avoid SctO2 values of 55% or below."

A second study (2), entitled "Mathematical model for describing cerebral oxygen desaturation in patients undergoing deep hypothermic circulatory arrest", was conducted by Dr. Gregory Fischer and colleagues at the Department of Anesthesiology and Cardiothoracic Surgery of Mount Sinai Medical Center in New York City. The study on 36 patients demonstrated that a mathematical model could be created that accurately described the rate of cerebral desaturation during circulatory arrest. These researchers concluded that the proposed model "can aid the clinician in determining the length of DHCA (deep hypothermic circulatory arrest) that can be undertaken safely and can be utilized to define the safest time point to commence DHCA."

Dr. Fischer, the Director of Adult Cardiothoracic Anesthesia, stated, "Currently, there is much heterogeneity among institutions regarding both timing and duration of circulatory arrest. Contemporary protocols are variable and are based on anecdotal or animal-model experiences. While our model must still be considered a work in progress, we hope our efforts will make the technique of circulatory arrest more scientific and enable intraoperative management that is tailored to the physiological requirements of the individual patient, which in turn will hopefully result in better outcomes."

About CASMED(R) - Monitoring What's Vital

CAS Medical Systems, Inc. is a leading developer and manufacturer of medical devices for non-invasive patient monitoring. The Company's FORE-SIGHT Absolute Cerebral Oximeter is the first cerebral oximeter available with FDA clearance for non-invasive, continuous measurement of absolute cerebral tissue oxygen saturation for neonates, infants, children and adults. This information helps avert brain damage or death during surgery and in critical care situations by allowing clinicians to identify patients with dangerously low levels of cerebral oxygen and intervene to reverse the condition.

The Company's product lines include the high-acuity monitoring capabilities of the FORE-SIGHT Cerebral Oximeter, the bedside patient monitoring line of vital signs and cardio-respiratory monitoring products, proprietary non-invasive blood pressure measurement technology, and supplies and service including blood pressure cuffs and products for neonatal intensive care. CASMED products are designed to meet the needs of a full spectrum of patient populations worldwide, ranging from adults to pediatrics and neonates.

For further information regarding CAS Medical Systems, Inc., visit the Company's website at


(1) Kazan R, Bracco D, Hemmerling TM. Reduced cerebral oxygen saturation measured by absolute cerebral oximetry during thoracic surgery correlates with postoperative complications. British Journal of Anaesthesia 2009;103(6):811-16.

(2) Fischer GW, Benni PB, Lin H-M, Satyapriya A, Afonso A, DiLuozzo G, Griepp RB, Reich DL. Mathematical model for describing cerebral oxygen desaturation in patients undergoing deep hypothermic circulatory arrest. British Journal of Anaesthesia Advance Access published November 20, 2009, doi:10.1093/bja/aep335.

Statements included in this press release, which are not historical in nature, are forward-looking statements made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 1995. Statements relating to the future financial performance of the Company are subject to many factors including, but not limited to, the customer acceptance of the products in the market, the introduction of competitive products and product development, the result of on-going litigation, commercialization and technological difficulties, the impact of actions and events involving key customers and vendors, and other risks detailed in the Company's Form 10-K for the year ended December 31, 2008 and other subsequent Securities and Exchange Commission filings.

Such statements are based upon the current beliefs and expectations of the Company's management and are subject to significant risks and uncertainties. Actual results may differ from those set forth in the forward-looking statements. When used in this press release the terms "anticipate", "believe", "estimate", "expect", "may", "objective", "plan", "possible", "potential", "project", "will" and similar expressions identify forward-looking statements. The forward-looking statements contained in this press release are made as of the date hereof, and we do not undertake any obligation to update any forward-looking statements, whether as a result of future events, new information or otherwise.

Source: CAS Medical Systems

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