Healthcare Industry News: drug-eluting balloon
News Release - August 8, 2012
Cardionovum(R) Expects to Launch Next-Generation Product: Drug-Eluting Coronary Stent System, “PROLIMUS Biograde”Company featured in IN VIVO magazine
BONN, Germany--(Healthcare Sales & Marketing Network)--Cardionovum GmbH announced today that it expects to launch in Europe in Q4 2012 a next-generation Sirolimus-eluting coronary stent system—PROLIMUS Biograde—which is designed to optimize long-term patient results. Unlike many state-of-the-art DES that are currently being marketed, PROLIMUS Biograde provides multiple pro-healing product features to promote early re-endothelialization.
The thin-stent strut design of PROLIMUS Biograde, just 71 microns, minimizes stent-metal-volume, and thus foreign-body effects, while providing uniform stent coverage through its strut architecture. In addition, the PROLIMUS Biograde stent architecture incorporates a diameter-depending 6-8-10 intermediate and closed-cell stent design intended to cover all vessel diameters with the same ratio. The goal of such design is to ensure a homogenous drug elution into the arterial tissue of the stented lesion segment.
Furthermore, Cardionovum´s new DES is designed to protect allergic patients against emission of metal ions. PROLIMUS Biograde is coated with Titanium, which is highly biocompatible and functions as a barrier against “metal-ion-bleeding” that prevents any stent-associated hypersensitivity reaction. Especially high-risk patients such as diabetics will benefit from this “following nature” stent philosophy of Cardionovum. Most coronary stent systems now available do not combine all of these clinically advantageous features, which contribute to lower restenosis complication.
“It is not only the drug on a stent that counts for the optimal patient treatment,” said Michael Orlowski, Ph.D., CEO of Cardionovum. “It also is critically important what remains in the patient´s artery for the patient´s lifetime, after drug elution has gone.”
The clinically anti-proliferative drug Rapamycin (Sirolimus) is coated onto PROLIMUS Biograde with the natural and biodegradable polylactide acid (PLA) polymer. Due to the controlled, six-weeks drug release, the long-term inhibition of re-endothelialisation is successfully eliminated. The new PROLIMUS Biograde DES technology promotes early re-endothelialisation and rapid healing. Its pro-healing Titanium stent surface promises long-term patient safety. The entire composition of all technical elements is designed to allow for a reduction of oral antiplatelet therapy in favor of the patient´s quality of life after stenting.
Based on its breakthrough and proprietary ‘PTX’ Gradient and High Intensity “EXPRESS” balloon-coated drug transfer technology, Cardionovum has developed and is commercializing in Europe clinically advanced medical therapies that are designed to improve upon current patient treatment standards for drug-eluting stents and drug-eluting balloons to treat coronary and peripheral artery disease.
NOTICE: Cardionovum’s products are not available for sale in the United States.
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