Healthcare Industry News:  ventilator 

Biopharmaceuticals Venture Capital

 News Release - September 10, 2014

Airway Therapeutics Raises $4.6 Million in Series A Funding

Financing Follows FDA Orphan Designation for Startup Working to Improve Outcomes for Very Premature Infants

CINCINNATI, OH--(Healthcare Sales & Marketing Network) - Airway Therapeutics, a biotechnology company working to prevent a debilitating lung condition in extremely premature infants, has secured $4.6 million in Series A financing. CincyTech led the round, with participation from Cincinnati Children's Hospital Medical Center, Queen City Angels and private investors.

Airway Therapeutics has developed a protein, recombinant human surfactant protein D (AT-100), that could prevent Bronchopulmonary Dysplasia (BPD), a serious, chronic lung disease that develops in preterm infants who require ventilation shortly after birth. These babies -- tens of thousands every year -- are at risk for BPD because they are born before their bodies produce surfactant, the substance that allows lungs to inflate with air. While ventilators help these babies to breathe, they can damage the immature lung tissue in a way that impedes full lung development and leads to BPD. Babies with BPD often have repeated pneumonias, hospitalizations and a higher incidence of asthma. Pre-clinical data suggest treatment with Airway's AT-100, in addition to the commercial surfactant that is currently available, more effectively prevents the infection and lung damage than does the current standard of care.

"The funding will enable Airway to propel the development of AT-100 significantly forward," said CEO Marc Salzberg, MD. "It will allow us to make progress along three critical and parallel paths: formulation, manufacturing and the design of the animal testing required in preparation for clinical trials involving patients."

"The business case for bringing AT-100 to market has never been stronger," said Mike Venerable, Managing Director at CincyTech. "This promising therapeutic is based on world class science and guided by an experienced team."

Airway's treatment is based on a decade of pioneering research by Dr. Jeffrey Whitsett, MD, at Cincinnati Children's Hospital Medical Center. "Cincinnati Children's is proud to be a part of this funding cycle to help accelerate AT-100 into the clinic," said Nicole Robinson, PhD, Assistant Vice President of CCHMC's Center for Technology Commercialization. "This much needed therapeutic has the potential to improve the outcome for some of our smallest and sickest babies."

In the months prior to the financing round, the case for AT-100 gained momentum on two continents. Both the US Food and Drug Administration and European regulators granted orphan designation to Airway. Orphan designation is an important milestone for companies working to cure rare diseases, offering financial incentives, prioritized review and market exclusivity.


Airway Therapeutics is a biotechnology company in Sharonville, Ohio that is developing a unique protein replacement therapy to prevent and treat lung disease in the most vulnerable patients, beginning with premature infants with extremely low birth weight. The treatment is based on a decade of research at Cincinnati Children's Hospital Medical Center.


CincyTech is a venture development organization whose mission is to drive talent and capital into promising startup companies in Southwest Ohio. Supported by grants from the Ohio Third Frontier, with matching grants from corporations, foundations, and local governments, CincyTech has $30 million under management across three for-profit seed funds and one follow-on fund.

Source: Airway Therapeutics

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