Healthcare Industry News:  Array BioPharma 

Biopharmaceuticals Oncology Distribution

 News Release - June 28, 2018

Avella Selected by Array BioPharma Inc. to distribute BRAFTOVI(TM) (encorafenib) and MEKTOVI(R) (binimetinib)

The specialty pharmacy will give patients access to this important new FDA-approved combination therapy for patients with advanced BRAF melanoma

PHOENIX, June 28, 2018 -- (Healthcare Sales & Marketing Network) -- Avella has announced that it will distribute BRAFTOVITM (encorafenib and MEKTOVIŽ (binimetinib), a combination therapy recently FDA approved for patients for the treatment of patients with unresectable or metastatic melanoma with a BRAFV600E or BRAFV600K mutation, as detected by an FDA-approved test.

Metastatic melanoma is the most serious, life-threatening type of skin cancer and is associated with low survival rates overall. Approximately 9,000 people are expected to die of melanoma in 2018. There are about 200,000 new cases of melanoma diagnosed worldwide each year, and approximately half of these have BRAF mutation. A gene mutation is an abnormal alteration in the DNA sequence that makes up a gene. Many new cancer therapies specifically target cells that have certain gene mutations rather than attacking all rapidly-dividing cells. This approach can make these therapies more effective than traditional chemotherapy and may also lead to less serious side effects.

BRAFTOVI is a BRAF inhibitor, which means it targets certain proteins within cells that have the BRAF mutation. This protein is responsible for cell growth. MEKTOVI is a MEK inhibitor and works by blocking proteins created by this particular gene mutation. The MEK gene works together with the BRAF gene, which is why combination therapies can be more effective than using either type of drug alone.

When used in combination, BRAFTOVI and MEKTOVI have been the first targeted therapy to demonstrate over 30 months median overall survival in a Phase 3 trial. This two-part, international, randomized Phase 3 trial evaluated the efficacy and safety of BRAFTOVI in combination with MEKTOVI compared to vemurafenib and encorafenib monotherapy in 921 patients with locally advanced, unresectable or metastatic melanoma with the BRAFV600 mutation.

"Unfortunately, melanoma rates have been rising steadily over the last 30 years and this aggressive cancer has taken far too many lives," said Leslie Yendro, Director of Business Development for Avella. "With the FDA-approval of this important new combination therapy, we can offer patients a treatment option that has demonstrated a meaningful impact on survival rates."

About Avella Specialty Pharmacy

Headquartered in Phoenix, Arizona, Avella Specialty Pharmacy is a National Accredited Specialty Pharmacy, providing individualized care and support to patients since 1996. Avella's clinical pharmacists and staff members are experts in managing complex disease states and providing compassionate care. The company offers a nationwide distribution service to complement its retail locations. In 2016, Avella was named Specialty Pharmacy of the Year by NASP, a nationally recognized pharmacy trade committee. Inc. Magazine's 2017 list of the 5,000 fastest-growing private companies in the country included Avella for the eleventh consecutive year and also recognized Avella as the fastest-growing woman-led company in 2015. In addition, the Arizona Corporate Excellence Awards named Avella Specialty Pharmacy as the second fastest-growing private company based in the state in 2016. For more information, please visit

Source: Avella

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